Ordförklaringar:

Publication

Once the results of the study are complete, it is time to start writing your report or article for publication in a scientific journal or other forum.

  • From idea to research question

    Health and medical care or clinical research?

    Compare your idea with previous research

    Search for knowledge among systematic analyses

    Search for gaps in scientific knowledge

    Use data found in registers

    Formulate the problem

    Points to consider

    Specific rules for medicinal products or medical devices

    Related information about ATMP

  • Start planning your clinical study

    Systems for data collection, data management and data storage

    A research plan is necessary for ethical review applications, and functions as a handbook

    Statistical analysis plan

    Information to study participants before consent

    Find out what insurance cover is available for the study participants

    Budget for all study costs

    Is a health economics evaluation of the study needed?

    Checklist to help plan studies on human

    To consider

    Specific rules for medicines and medical devices

    Authorisation and trial protocol

    Roles and responsibilities under ICH-GCP

    Related information about ATMP

  • Apply for authorisation for your clinical study

    Apply for ethical review

    If your study is also reviewed by the Swedish Medical Products Agency

    Research projects in which study participants are irradiated

    Apply for access to biobank samples

    Handle personal data correctly

    Register your study before it starts

    Agreement on the conduct of clinical studies

    Templates and support documents for clinical trials

    Points to consider

    Specific rules for medicines and medical devices

    Apply for authorisation for a clinical trial of a medicinal product

    How to apply for a clinical trial of a medicinal product

    If the study involves biobank samples

    Related information about ATMP

  • Conduct the study in accordance with approved documentation

    Study participants must provide written consent

    Collect and manage study data

    Requirements for Computerized Systems

    Changes to the study protocol after approval

    Points to consider

    Specific rules for medicines and medical devices

    Establish trial master files

    Conduct of monitoring

    Compile an annual safety report

    Related information about ATMP

  • Plan analysis and data manage­ment early

    Analysis and study design must be aligned

    Studies with a confirmatory purpose

    Studies with an exploratory purpose

    Data management after the study has been completed

    Analysis of study data

    Specific rules for medical devices

    Related information about ATMP

  • Archiving in the research process

    Public documents must be archived

    Where is research material archived?

    Digital archiving

    Plan archiving at an early stage

    Specific requirements for certain research areas

    Screening of personal data

    Points to consider

    Specific rules for medicinal products and medical devices

    Archiving of clinical trials of medicinal products

    Related information about ATMP

Publish the research

Medical research aims to improve human health. To achieve this, research results must be communicated in a clear and understandable way and reach the intended audience.

Writing a scientific article

Scientific articles make it possible to disseminate research results to research colleagues, healthcare professionals and the general public. In the long term, the results can contribute to development and serve as a basis for change in healthcare.

Before an article is published, it is reviewed by other researchers in the field through a process known as peer review. The reviewers are subject-matter experts, and the review is conducted to ensure that the research meets a high scientific standard.

Write clearly and highlight the message

A scientific article becomes more accessible when it is written in clear and straightforward language. The article should:

  • provide a clear answer to the scientific research question
  • have a clearly formulated aim
  • clearly convey its main message

Follow the journal’s instructions

The websites of scientific journals provide detailed instructions for authors regarding:

  • what types of publications the journal accepts
  • which headings should be included
  • how the publication should be formatted
  • which rules apply to figures and tables

Structure of the article

A typical medical scientific article is often structured as follows:

  • Introduction – Why was the study conducted?
  • Methods – What was done?
  • Results – What were the outcomes?
  • Discussion – What do the results mean?

Choosing a journal

Choosing the right journal is an important part of the publication process. The choice affects how well the research results are disseminated and to whom.

Consider the following when choosing a journal

  • which journals exist within the subject area
  • how best to reach the target audience
  • the journal’s impact factor

The choice of journal should be made as early as possible so that the manuscript can be adapted from the outset. The choice is guided by the strength of the message, meaning both the scientific quality and the novelty of the results.

Impact factor

Journals are ranked according to how often their articles are cited; this is referred to as the impact factor.

The International Scientific Institute provides searchable lists of impact factors for indexed journals. Information on impact factor is also often available on the journals’ own websites.

Searchable lists of the impact factors of indexed journals, website of the International Scientific Institute External link.

Get help choosing a journal

You may wish to seek advice and support from a librarian within your organisation or higher education institution when choosing a journal.

Publish with open access

Open access means that scientific publications funded by public resources should be made digitally available to everyone, free of charge.

National guidelines for open access to scientific information is available on the website of the Swedish Research Council. You can read more about open access and open archives at Swedish HEIs on the website of the National Library of Sweden.

Publishing the results in a public database

Results from clinical trials must be registered in the public database where the study was previously registered – regardless of the study outcome.

Many scientific journals require studies to be registered for the results to be eligible for publication. In practice, this means that there is a registration requirement even for studies that are not clinical trials of medicinal products.

Informing study participants of the study results

Study participants should be informed that the study has been completed and about the study results, in accordance with what is stated in the written information provided to participants.

The Swedish Ethical Review Authority has developed guidance on how information to study participants should be designed.

More information and support:

Points to consider

  • Which journal is appropriate for publishing the study results?
  • Does the publication meet any open access requirements?
  • Does the publication follow the selected journal’s instructions?

Specific rules for medicinal products and medical devices

There are specific rules to attend to regarding clinical investigations of medical devices.

EU Regulation (EU) No 536/2014

For clinical trials of medicinal products conducted under Regulation (EU) No 536/2014, the following applies:

The sponsor shall notify via CTIS within 15 days that the trial has been completed:

  • in each participating Member State
  • in all participating Member States

Within 1 year after completion of the trial, the sponsor shall submit via CTIS:

  • a summary of the trial results
  • a summary of the results written for laypersons

This applies regardless of the results obtained in the trial.

For clinical trials involving children, where:

  • the investigational medicinal product is authorised, and
  • the sponsor is the holder of the marketing authorisation (MAH),

the summary of the results shall be submitted within 6 months after completion of the trial.

Sponsor's responsibility for reporting of final results of clinical trial, Swedish Medicinal Products Agency Website External link.

Previous EU Directive 2001/20/EC

For clinical trials that have been registered in EudraCT and completed before 30 January 2025 (and not transferred to CTIS) shall:

  • Summary of the results of the clinical trial must be published in the EU database (EudraCT)
  • A clinical study report be prepared

Information about completed trials, Swedish Medical Products Agency website External link.

Medical devices in the EU are divided into two regulatory categories, each following different regulations. For medical devices, the EU Regulation on Medical Devices (MDR) applies. New regulations came into effect within the EU from May 26, 2021, and additional regulations apply in Sweden from July 15, 2021.

Writing a final report

For medical technical clinical trials, a final report must be written according to instructions on the Swedish Medical Products Agency's website.

The final report does not need to be submitted to the Swedish Medical Products Agency for trials that have begun before the application of the EU regulation on medical devices (26 May 2021). The Swedish Medical Products Agency may, however, specifically request access to the final report.

Final report for trials that begin after application of the EU regulation on medical devices (26 May 2021) must always be submitted to the Swedish Medical Products Agency.Guidelines for the content of the report are available in EU regulation on medical devices, Appendix XV and in ISO 14155:2020, Annex D.

The written final report shall include study data analysed in accordance with what has been previously defined in the clinical trial plan. The final report shall be reviewed by the participating investigators, and the final report shall be signed by the sponsor and principal investigator, or the coordinating investigator for multi-centre studies. The report and an easy-to-understand summary shall be submitted to the Swedish Medical Products Agency latest one year after the end of the clinical trial, or latest after three months if the trial was terminated prematurely or suspended.

Publish the results in a public database

Results from clinical investigations of medical devices shall be registered in the public database, where the study was previously registered, regardless of the results. Review whether the journal you intend to publish in has specific requirements for registration in a specific database.

Medical devices in the EU are regulated and divided into two categories that follow different frameworks. For in vitro diagnostic medical devices, the EU Regulation 2017/746 on in vitro diagnostic medical devices (IVDR) applies. New regulations came into effect within the EU from May 26, 2022.

Writing a final report

For clinical performance studies on in vitro diagnostic products, a study report must be written in accordance with the EU regulation on medical devices for in vitro diagnostics, Annex XIII, Part A section 2.3.3 and Annex A in ISO 20916: 2019.

A study report must be signed by a doctor or another responsible competent person and must, among other things, contain results and conclusions of the study, including negative results. The report shall contain so much information that an independent party shall be able to understand it without reference to other documents.

The report and an easy-to-understand summary must be sent to the Swedish Medical Products Agency within one year after a clinical performance study has been completed or no later than three months after it has been terminated prematurely or temporarily interrupted.

Publish the results in a public database

Results from clinical performance studies must be recorded in the public database, where the study was previously registered, regardless of the results. Review whether the journal you intend to publish in has specific requirements for registration in a specific database.

EU regulation on in vitro diagnostic medical devices, European Medicines Agency's website External link.

ISO 20916: 2019, SIS' website External link.

Related information about ATMP

Published: